Paraoxonase-1 Gene Q192R Polymorphism and Reactive Oxygen Metabolites
نویسندگان
چکیده
منابع مشابه
Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer.
Increased oxidative stress can help promote carcinogenesis, including development of renal cell carcinoma. The enzyme protects low-density lipoproteins from oxidation and can be a factor in this process. PON1 Q192R and L55M paraoxonase gene polymorphisms were assessed in 60 renal cell carcinoma patients and 60 healthy controls. Genotypes were examined by PCR; the restriction enzyme AlwI was use...
متن کاملQ192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men
AIMS Essential hypertension is characterized by increased reactive oxygen species (ROS) generation harmful for insulin sensitivity and nitric oxide (NO)-mediated vasomotor function, a noxious effect that paraoxonase (PON)1, an antioxidant circulating high-density lipoprotein (HDL)-bound esterase, may counteract. The PON1 gene contains several polymorphisms including a glutamine (Q) to arginine ...
متن کاملParaoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.
BACKGROUND Recently published data indicate that the paraoxonase-1 (PON1) Q192R genotype-and not as previously shown activity of cytochrome P450 (CYP) 2C19-is the major determinant of metabolic bioactivation of clopidogrel and thereby variability of antiplatelet effect of clopidogrel. We sought to investigate whether the PON1 Q192R gene polymorphism affects platelet reactivity in patients under...
متن کاملLack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran.
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 healthy ...
متن کاملParaoxonase-1 Q192R polymorphism and risk of sporadic amyotrophic lateral sclerosis.
To the Editor: Paraoxonase-1 (PON1) is an HDL-associated enzyme which hydrolyzes the oxidized lipids in LDL and organophosphate insecticides, pesticides, and nerve gases. The PON1 gene is located on chromosome 7q21.3-q22.1. The Q192R polymorphism influences the enzyme activity. Carriers of RR192 genotype present with the lowest ability to protect LDL from oxidation, the lowest hydrolytic activi...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2012
ISSN: 0300-0605,1473-2300
DOI: 10.1177/147323001204000431